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KMID : 0438219740110010499
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Korea University Medical Journal
1974 Volume.11 No. 1 p.499 ~ p.510
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An Experimental Study on Water and Electrolytes in the Tissue of the Uterus and Cerebral Cortex of Mature Female Rabbits by Resepine Adrministration
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李明秀/Rhee, Myong Soo
李壽鍾/Lee, Soo Chong
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Abstract
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Reserpine, one of the rouwolfian alkaloid has been used as hyptoensive and diuretics not only for toxemia of pregnancy but also for other conditions in the obstetrical and gynecological field. Althogh reserpine decreases blood pressure, it has a number of untoward side effects such as inhibition of gooadal stimulation, and lso responds to hypothalamus and pituitary adrenal axis.
Author has attempted to clarify the effects of reserpine on water and electrolytes in the tissue of the uterus and cerebral cortex of mature female rabbits weighing around 2.Okg.
A group of rabbits preconditioned with 50 I. U. /kg of HCG and another group with 1.5mg/kg of reserpine plus 50 I. U. /kg HCG were observed 24 hours after conditioning.
The results obtained were as follows:
1. The HCG preconditioned mature female rabbits showed acceleration in maturation of the follicles and ovulation in the ovaries but in the reserpine plus HCG preconditioned group showed corpus luteum.
2. Changes in electrolyte levels in serum of the HCG preconditioned rabbits showed an increase in sodium, potassium and calcium levels and a decrease in chloride and magnesium levels. The level of magnesium in the reserpine plus HCG preconditioned group showed remarkable decreaaed.
3. Water and calcium of the uterine tissue in the HCG preconditioned mature female rabbits showed increase in contents compared to the normal group and a decrease in chloride, sodium and magnesium. In the reserpine plus HCG preconditioned group chloride and potassium, magnesium were remarkable decreased in each level. HCG administration showed no_supression in electorlytes in uterine tissue. . 4. Contents of water and electrolytes in cerebral cortex of mature female rabbits of HCG preconditioned group showed an increase chloride, sodium and potassium levels and a decrease in water and magnesium levels.
5. Water content of the cerebral cortex of normal mature female rabbits produced no appreciable "change than that of the uterine tissue. The reserpine plus HCG preconditioned group showed water
content in the uterus was higher than that of the cerebral cortex.
6. Chloride content of the uterine tissue in normal showed higher than that of cerebral cortex and HCG preconditioned group showed no siginificant difference in chloride content. The reserpine plus HCG preconditioned group, chloride content of cerebral cortex showed higher than that of the uterine tissue.
7. Sodium content of the uterine tissue in normal and HCG preconditioned one showed higher level than that of the cerebral cortex, the reserpine plus HCG preconditioned group were higher than those of the cerebral cortex.
8. The level of potassium of the uterine tissue in normal, HCG preconditioned and the reserpine plus HCG precitioned group were higher than those of the cereral corex.
9. The level of calcium of the uterine tissue and cerebral cortex in normal were same level. The level of calcium of the uterine tissue in HCG preconditioned and the reserpine plus HCG preconditioned group were higher than that of the cerebral cortex.
10. The level of content of magnesium of the uterine tissue in normal, HCG preconditioned and the reserpine olus HCG preconditioned group showed no change compared to the magnesium of the cerebral cortex.
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